Our research 相關研究

Our Research Team has adopted an interdisciplinary approach to studying the local epidemiology of viral hepatitis for informing the development of effective public health interventions. Our epidemiological studies has enhanced the understanding of the distribution and determinants of the diseases in Hong Kong, in the contexts of time, place and person.

  • Hepatitis C virus infection

    Hepatitis C virus (HCV) infection is a surrogate marker of high risk behaviours in injection drug users (IDU). Starting from seroprevalence studies in a cohort of IDU in the vicinity of methadone clinics in Hong Kong, our HCV epidemiological studies have been expanded to involve molecular investigation, spatial exploration and multilevel analysis on the vulnerability of IDU. Alternative risk factors to HCV infection in non-IDU is another theme of ongoing research.

  • Hepatitis E virus infection

    In response to the increasing number of acute hepatitis E virus (HEV) infection in Hong Kong, studies have been conducted to determine the seroprevalence of HEV infection by age group and gender and assess the risk factors associated with HEV seropositivity, particularly in some subpopulations at varying risk for acquiring HEV or having fulminant hepatitis.

我們的研究團隊一直採取誇領域的研究方法,探討本地病毒性肝炎的流行情況,為制訂有效的公共衛生措施提供科研數據。我們的流行病學研究從疾病發生的時間、地點及人物等各方面入手,著力了解病毒性肝炎的分佈及相關的發病或感染因素。

  • 丙型肝炎病毒感染

    丙型肝炎病毒感染一直是注射毒品人士曾進行高風險行為的指標。從了解美沙酮診所附近的注射毒品人士的感染情況開始,我們的流行病學研究擴展至病毒的分子探究、空間分佈及多層分析等範疇,從而更深入了解注射毒品人士的感染風險。另外,與注射毒品無關的丙型肝炎病毒感染亦是研究團隊現正探討的研究課題。

  • 戊型肝炎病毒感染

    鑑於急性戊型肝炎病毒的感染數字在香港有所上升,研究團隊曾對各年齡組別及性別過去感染戊型肝炎病毒的情況進行研究,並評估感染的相關風險因素,特別針對部分較高感染風險或較易出現嚴重肝炎的群組。

Selected publication 期刊文章

  • Wong NS, Lee CK, Ng SC, Wong HK, Chan DPC, Lee SS. Prevalence of hepatitis C infection and its associated factors in healthy adults without identifiable route of transmission. J Viral Hepat. 2018 Feb;25(2):161-170. doi: 10.1111/jvh.12804.
  • Chan DP, Lee KC, Lee SS. Epidemiology of hepatitis E infection in Hong Kong. Hong Kong Med J. 2017 Aug;23 Suppl 5(4):31-35.
  • Chan DP, Lee KC, Lee SS, Tan TY. Community-based molecular epidemiology study of hepatitis C virus infection in injection drug users. Hong Kong Med J. 2017 Aug;23 Suppl 5(4):27-30.
  • Chan DP, Sun HY, Wong HT, Lee SS, Hung CC. Sexually acquired hepatitis C virus infection: a review. Int J Infect Dis. 2016 Aug;49:47-58. doi: 10.1016/j.ijid.2016.05.030.
  • Chan DP, Lin AW, Wong KH, Wong NS, Lee SS. Diverse origins of hepatitis C virus in HIV co-infected men who have sex with men in Hong Kong. Virol J. 2015 Aug 8;12:120. doi: 10.1186/s12985-015-0355-8.
  • Wong NS, Chan PC, Lee SS, Lee SL, Lee CK. A multilevel approach for assessing the variability of hepatitis C prevalence in injection drug users by their gathering places. Int J Infect Dis. 2013 Mar;17(3):e193-8. doi: 10.1016/j.ijid.2012.10.004.
  • Chan DP, Lee SS, Lee KC. The effects of widespread methadone treatment on the molecular epidemiology of hepatitis C virus infection among injection drug users in Hong Kong. J Med Virol. 2011 Jul;83(7):1187-94. doi: 10.1002/jmv.22099.
  • Lee SS. Prevalence of hepatitis C infection in injection drug users in Hong Kong. Hong Kong Med J. 2009 Dec;15 Suppl 8:45-6.
  • Tan Y, Wei QH, Chen LJ, Chan PC, Lai WS, He ML, Kung HF, Lee SS. Molecular epidemiology of HCV monoinfection and HIV/HCV coinfection in injection drug users in Liuzhou, Southern China. PLoS One. 2008;3(10):e3608. doi: 10.1371/journal.pone.0003608.
  • Lee KC, Lim WW, Lee SS. High prevalence of HCV in a cohort of injectors on methadone substitution treatment. J Clin Virol. 2008 Apr;41(4):297-300. doi: 10.1016/j.jcv.2007.09.013.